Conformational changes and flexibility in T-cell receptor recognition of peptide–MHC complexes

@inproceedings{Armstrong2008ConformationalCA,
  title={Conformational changes and flexibility in T-cell receptor recognition of peptide–MHC complexes},
  author={Kathryn M. Armstrong and Kurt H. Piepenbrink and Brian M. Baker},
  booktitle={The Biochemical journal},
  year={2008}
}
A necessary feature of the immune system, TCR (T-cell receptor) cross-reactivity has been implicated in numerous autoimmune pathologies and is an underlying cause of transplant rejection. Early studies of the interactions of alphabeta TCRs (T-cell receptors) with their peptide-MHC ligands suggested that conformational plasticity in the TCR CDR (complementarity determining region) loops is a dominant contributor to T-cell cross-reactivity. Since these initial studies, the database of TCRs whose… CONTINUE READING

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