Conformational change opening the CFTR chloride channel pore coupled to ATP-dependent gating.


Opening and closing of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel are controlled by ATP binding and hydrolysis by its nucleotide binding domains (NBDs). This is presumed to control opening of a single "gate" within the permeation pathway, however, the location of such a gate has not been described. We used patch clamp… (More)
DOI: 10.1016/j.bbamem.2011.12.025