Conformational change of pseudouridine 55 synthase upon its association with RNA substrate.

@article{Phannachet2004ConformationalCO,
  title={Conformational change of pseudouridine 55 synthase upon its association with RNA substrate.},
  author={Kulwadee Phannachet and Raven H Huang},
  journal={Nucleic acids research},
  year={2004},
  volume={32 4},
  pages={1422-9}
}
Pseudouridine 55 synthase (Psi55S) catalyzes isomerization of uridine (U) to pseudouridine (Psi) at position 55 in transfer RNA. The crystal structures of Thermotoga maritima Psi55S, and its complex with RNA, have been determined at 2.9 and 3.0 A resolutions, respectively. Structural comparisons with other families of pseudouridine synthases (PsiS) indicate that Psi55S may acquire its ability to recognize a stem-loop RNA substrate by two insertions of polypeptides into the PsiS core. The… CONTINUE READING
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Chips off the old block

  • H. Pan, S. Agarwalla, D. T. Moustakas, J. Finer-Moore, R. M. Stroud
  • Nat . Struct . Biol .
  • 2002

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