Conformational and physicochemical DNA features specific for transcription factor binding sites

  title={Conformational and physicochemical DNA features specific for transcription factor binding sites},
  author={Julia V. Ponomarenko and Mikhail P. Ponomarenko and Anatoly S. Frolov and Denis G. Vorobiev and G. Christian Overton and Nikolay A. Kolchanov},
  volume={15 7-8},
MOTIVATION A reliable recognition of transcription factor binding sites is essential for analysis of regulatory genomic sequences. The experimental data make evident an important role of DNA conformational features for site functioning. However, Internet-available tools for revealing conformational and physicochemical DNA features significant for the site functioning and subsequent use of these features for site recognition have not been developed up to now. RESULTS We suggest an approach for… CONTINUE READING
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Stabilities of nearest-neighbor doublets in double-helical DNA determined by fitting calculated melting profiles to observed profiles

  • O. Gotoh, Y. Tagashira
  • Biopolymers
  • 1981
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