Conformational and chemical selection by a trans-acting editing domain.


Molecular sieves ensure proper pairing of tRNAs and amino acids during aminoacyl-tRNA biosynthesis, thereby avoiding detrimental effects of mistranslation on cell growth and viability. Mischarging errors are often corrected through the activity of specialized editing domains present in some aminoacyl-tRNA synthetases or via single-domain trans-editing… (More)
DOI: 10.1073/pnas.1703925114


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@article{Danhart2017ConformationalAC, title={Conformational and chemical selection by a trans-acting editing domain.}, author={Eric M. Danhart and Marina M. Bakhtina and William A. Cantara and Alexandra B Kuzmishin and Xiao Ma and Brianne L. Sanford and Marija Ko{\vs}uti{\'c} and Yuki Goto and Hiroaki Suga and Kotaro Nakanishi and Ronald Micura and Mark P. Foster and Karin Musier-Forsyth}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2017}, volume={114 33}, pages={E6774-E6783} }