Conformational analysis of cyproheptadine hydrochloride.

  title={Conformational analysis of cyproheptadine hydrochloride.},
  author={M. Sadek and D. Craik and J. Hall and P. Andrews},
  journal={Journal of medicinal chemistry},
  volume={33 4},
A nuclear magnetic resonance and theoretical study on the conformations and molecular flexibility of cyproheptadine hydrochloride (1) is reported. In the 1H NMR spectrum of 1 in CDCl3, two conformational forms are observed to occur in an approximate ratio of 1:4. In both forms, NOE and coupling constant measurements suggested that the terminal N-methyl group is equatorial. NOE experiments identified the more populated conformer (labeled D) as similar to the form seen in the X-ray crystal… Expand
14 Citations
Cyproheptadine analogues: synthesis, antiserotoninergic activity, and structure-activity relationships.
LC-MS and NMR determination of a dichloromethane artifact adduct, cyproheptadine chloromethochloride.
Developments in antihistamines (H1).
  • A. Saxena, M. Saxena
  • Chemistry, Medicine
  • Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques
  • 1992