Conformational analysis of bacitracin A, a naturally occurring lariat

  title={Conformational analysis of bacitracin A, a naturally occurring lariat},
  author={Miquel Pons and Miguel Feliz and Maria Ant{\`o}nia Molins and Ernest Giralt},
The proton nmr spectra of bacitracin A in H2O and DMSO‐d6 have been assigned and the conformational behavior of the peptide in the two solvents has been compared. Although bacitracin A shows a conformational equilibrium between at least two conformations differing in the relative position of the cyclic and linear domains of the molecule, the spectra in water can be interpreted in terms of a preferred conformation in which the linear part is folded over the cyclic moiety and a turn is present… 

1 Metalloproteins and Metallopeptides – Natural Metallofoldamers

It is instructive to discuss the effect of metal ions or cofactors on the conformational changes of proteins prior to and during their actions, and by comparing the folding of metallopeptides and metalloproteins to those whose conformations take place in the absence ofMetal ions can provide further structural and functional information on the metal ions in the former molecules.

High-resolution crystal structure reveals molecular details of target recognition by bacitracin

Bacitracin’s efficient sequestration of its target represents a previously unseen mode for the recognition of lipid pyrophosphates, and suggests new directions for the design of next-generation antimicrobial agents.


The compound exhibited good antibacterial activity against Bacillus subtilis, Staphyloccus aureous, Escherrichia coli, Pseudomonas aeruginosa, and good antifungal activity against candida albicans.

Structure and function of “metalloantibiotics”

  • L. Ming
  • Chemistry, Biology
    Medicinal research reviews
  • 2003
Although most antibiotics do not need metal ions for their biological activities, there are a number of antibiotics that require metal ions to function properly, such as bleomycin, streptonigrin, and bacitracin, which are the title subjects of this review.

State-of-art on gel technologies for transdermal delivery of bacitracin

Dissertacao de mestrado em Tecnologias do Medicamento, apresentada a Faculdade de Farmacia da Universidade de Coimbra



Binding of nickel and zinc ions to bacitracin A.

A model for divalent metal ion binding to bacitracin is suggested and it is proposed that the metal coordinates directly to the glutamate carboxyl, the histidine imidazole, and the thiazoline ring.

NMR of proteins and nucleic acids

The NMR Assignment Problem in Biopolymers, two-Dimensional NMR With Proteins and Nucleic Acids, and Sequence-Specific Resonance Assignments.

Investigation of exchange processes by two‐dimensional NMR spectroscopy

A new general technique for the investigation of exchange processes in molecular systems is proposed and demonstrated. Applications comprise the study of chemical exchange, of magnetization transfer