Conformational analysis of bacitracin A, a naturally occurring lariat

  title={Conformational analysis of bacitracin A, a naturally occurring lariat},
  author={M. Pons and M. Feliz and M. Ant{\`o}nia Molins and E. Giralt},
  • M. Pons, M. Feliz, +1 author E. Giralt
  • Published 1991
  • Chemistry, Medicine
  • Biopolymers
  • The proton nmr spectra of bacitracin A in H2O and DMSO‐d6 have been assigned and the conformational behavior of the peptide in the two solvents has been compared. Although bacitracin A shows a conformational equilibrium between at least two conformations differing in the relative position of the cyclic and linear domains of the molecule, the spectra in water can be interpreted in terms of a preferred conformation in which the linear part is folded over the cyclic moiety and a turn is present… CONTINUE READING
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