Conformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis.


Molecular recognition plays a central role in biology, and protein dynamics has been acknowledged to be important in this process. However, it is highly debated whether conformational changes happen before ligand binding to produce a binding-competent state (conformational selection) or are caused in response to ligand binding (induced fit). Proposals for… (More)
DOI: 10.1016/j.celrep.2015.12.010


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