Conformational Requirement for Lysine Hydroxylation in Collagen

  title={Conformational Requirement for Lysine Hydroxylation in Collagen},
  author={Ping Jiang and Vettai S. AnanthanarayananS},
  • Ping Jiang, Vettai S. AnanthanarayananS
  • Published 2001
An attempt has been made to understand the conformational determinants that govern the hydroxylation of selected lysyl residues in the nascent collagen molecule by lysyl hydroxylase (EC A series of peptide substrates of the enzyme, ranging in length from 3 to 12 residues, were synthesized. These included: tert-butyloxylcarbonyl (t-Boc)-Ile… CONTINUE READING