Conformational Flexibility Differentiates Naturally Occurring Bet v 1 Isoforms

Abstract

The protein Bet v 1 represents the main cause for allergic reactions to birch pollen in Europe and North America. Structurally homologous isoforms of Bet v 1 can have different properties regarding allergic sensitization and Th2 polarization, most likely due to differential susceptibility to proteolytic cleavage. Using NMR relaxation experiments and… (More)
DOI: 10.3390/ijms18061192

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