Conformational Ensemble and Biological Role of the TCTP Intrinsically Disordered Region: Influence of Calcium and Phosphorylation.

@article{Malard2018ConformationalEA,
  title={Conformational Ensemble and Biological Role of the TCTP Intrinsically Disordered Region: Influence of Calcium and Phosphorylation.},
  author={Florian Malard and Nadine Assrir and Mou{\^a}d Alami and Samir Messaoudi and Ewen Lescop and T{\^a}p Ha-Duong},
  journal={Journal of molecular biology},
  year={2018},
  volume={430 11},
  pages={1621-1639}
}
The translationally controlled tumor protein (TCTP) is a multifunctional protein that may interact with many other biomolecules, including itself. The experimental determinations of TCTP structure revealed a folded core domain and an intrinsically disordered region, which includes the first highly conserved TCTP signature, but whose role in the protein… CONTINUE READING