Conformational Dynamics and Antigenicity in the Disordered Malaria Antigen Merozoite Surface Protein 2

@inproceedings{MacRaild2015ConformationalDA,
  title={Conformational Dynamics and Antigenicity in the Disordered Malaria Antigen Merozoite Surface Protein 2},
  author={Christopher A MacRaild and Milan Zachrdla and Dean W. Andrew and Bankala Krishnarjuna and Jiř{\'i} Nov{\'a}{\vc}ek and Luk{\'a}{\vs} Ž{\'i}dek and Vladimir Sklenar and Jack S. Richards and James G Beeson and Robin F. Anders and Raymond S. Norton},
  booktitle={PloS one},
  year={2015}
}
Merozoite surface protein 2 (MSP2) of Plasmodium falciparum is an abundant, intrinsically disordered protein that is GPI-anchored to the surface of the invasive blood stage of the malaria parasite. Recombinant MSP2 has been trialled as a component of a malaria vaccine, and is one of several disordered proteins that are candidates for inclusion in vaccines for malaria and other diseases. Nonetheless, little is known about the implications of protein disorder for the development of an effective… CONTINUE READING
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Overcoming antigenic diversity by enhancing the immunogenicity of conserved epitopes on the malaria vaccine candidate apical Dynamics and Antigenicity in the Disordered Malaria Antigen MSP2

  • S Dutta, LS Dlugosz, DR Drew, X Ge, D Ababacar, YI Rovira
  • PLOSONE | DOI:10.1371/journal.pone.0119899 March
  • 2015
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