Conformational Coupling between Receptor and Kinase Binding Sites through a Conserved Salt Bridge in a Signaling Complex Scaffold Protein

@inproceedings{Ortega2013ConformationalCB,
  title={Conformational Coupling between Receptor and Kinase Binding Sites through a Conserved Salt Bridge in a Signaling Complex Scaffold Protein},
  author={Davi R. Ortega and Guoya Mo and Kwangwoon Lee and Hongjun Zhou and J{\'e}r{\^o}me Baudry and Frederick W. Dahlquist and Igor B. Zhulin},
  booktitle={PLoS Computational Biology},
  year={2013}
}
Bacterial chemotaxis is one of the best studied signal transduction pathways. CheW is a scaffold protein that mediates the association of the chemoreceptors and the CheA kinase in a ternary signaling complex. The effects of replacing conserved Arg62 of CheW with other residues suggested that the scaffold protein plays a more complex role than simply binding its partner proteins. Although R62A CheW had essentially the same affinity for chemoreceptors and CheA, cells expressing the mutant protein… CONTINUE READING