Conformational Changes in the Orai1 C-Terminus Evoked by STIM1 Binding

@inproceedings{TiradoLee2015ConformationalCI,
  title={Conformational Changes in the Orai1 C-Terminus Evoked by STIM1 Binding},
  author={Leidamarie Tirado-Lee and Megumi Yamashita and Murali Prakriya and Mohamed Trebak},
  booktitle={PloS one},
  year={2015}
}
Store-operated CRAC channels regulate a wide range of cellular functions including gene expression, chemotaxis, and proliferation. CRAC channels consist of two components: the Orai proteins (Orai1-3), which form the ion-selective pore, and STIM proteins (STIM1-2), which form the endoplasmic reticulum (ER) Ca2+ sensors. Activation of CRAC channels is… CONTINUE READING