Conformational Changes and Signaling in Cell and Matrix Physics

  title={Conformational Changes and Signaling in Cell and Matrix Physics},
  author={Andr{\'e} E. X. Brown and Dennis E Discher},
  journal={Current Biology},
Physical factors drive evolution and play important roles in motility and attachment as well as in differentiation. As animal cells adhere to survive, they generate force and 'feel' various mechanical features of their surroundings, with mechanosensory mechanisms based in part on force-induced conformational changes. Single-molecule methods for in vitro nano-manipulation, together with new in situ proteomic approaches that exploit mass spectrometry, are helping to identify and characterize the… CONTINUE READING