Conformation state-sensitive antibodies to G-protein-coupled receptors.

  title={Conformation state-sensitive antibodies to G-protein-coupled receptors.},
  author={Achla Gupta and Fabien M. D{\'e}caillot and Ivone Gomes and Oleg Tkalych and Andrea S. Heimann and Emer Suavinho Ferro and Lakshmi A Devi},
  journal={The Journal of biological chemistry},
  volume={282 8},
A growing body of evidence indicates that G-protein-coupled receptors undergo complex conformational changes upon agonist activation. It is likely that the extracellular region, including the N terminus, undergoes activation-dependent conformational changes. We examined this by generating antibodies to regions within the N terminus of micro-opioid receptors. We find that antibodies to the midportion of the N-terminal tail exhibit enhanced recognition of activated receptors, whereas those to the… CONTINUE READING


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