Conformation-specific antibodies reveal distinct actin structures in the nucleus and the cytoplasm.

@article{Schoenenberger2005ConformationspecificAR,
  title={Conformation-specific antibodies reveal distinct actin structures in the nucleus and the cytoplasm.},
  author={C A Schoenenberger and Sabine Buchmeier and Melanie Boerries and Rosmarie Suetterlin and Ueli Aebi and Brigitte M. Jockusch},
  journal={Journal of structural biology},
  year={2005},
  volume={152 3},
  pages={157-68}
}
For many years the existence of actin in the nucleus has been doubted because of the lack of phalloidin staining as well as the failure to document nuclear actin filaments by electron microscopy. More recent findings reveal actin to be a component of chromatin remodeling complexes and of the machinery involved in RNA synthesis and transport. With distinct functions for nuclear actin emerging, the quest for its conformation and oligomeric/polymeric structure in the nucleus has resumed importance… CONTINUE READING

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