Conformation of the EPEC Tir protein in solution: investigating the impact of serine phosphorylation at positions 434/463.


The translocated intimin receptor (Tir) is a key virulence factor of enteropathogenic Escherichia coli and related bacteria. During infection, Tir is translocated via a type III secretion system into host intestinal epithelial cells, where it inserts into the target cell membrane and acts as a receptor for the bacterial adhesin intimin. The effects of… (More)


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