Conformation of Met5-enkephalin determined by high field PMR spectroscopy

  title={Conformation of Met5-enkephalin determined by high field PMR spectroscopy},
  author={B. Roques and Christiane Garbay-Jaureguiberry and Robert Oberlin and Marc J. O. Anteunis and Anil K. Lala},
THE discovery by Hughes et al.1 that peptides (the enkephalins) could be the endogenous agonists of opiates in brain represents a challenge to medical chemistry both in its fundamental aspects and for the possible development of new therapeutic approaches. To understand how non-peptidic substances belonging to various chemical classes can mimic the action of the pentapeptide enkephalins it is first necessary to determine the spatial arrangement of the latter. We have thus synthesised large… CONTINUE READING