Conformation of Lys-plasminogen and the kringle 1-3 fragment of plasminogen analyzed by small-angle neutron scattering.

@article{Ramakrishnan1991ConformationOL,
  title={Conformation of Lys-plasminogen and the kringle 1-3 fragment of plasminogen analyzed by small-angle neutron scattering.},
  author={Venkatesh Ramakrishnan and L{\'a}szl{\'o} Patthy and Walter F. Mangel},
  journal={Biochemistry},
  year={1991},
  volume={30 16},
  pages={3963-9}
}
Native human Glu-plasminogen (Glu1-Asn791) was previously shown to have a radius of gyration of 39 A and a shape best described by a prolate ellipsoid [Mangel, W. F., Lin, B., & Ramakrishnan, V. (1990) Science 248, 69-73]. Upon occupation of a weak lysine-binding site, the shape reversibly changes to that best described by a Debye random coil with a radius of gyration of 56 A. Conversion from the closed to the open form is not accompanied by any change in secondary structure, hence the closed… CONTINUE READING

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