Conformation-dependent regulation of inward rectifier chloride channel gating by extracellular protons.

Abstract

We have investigated the gating properties of the inward rectifier chloride channel (Cl(ir)) from mouse parotid acinar cells by external protons (H(+)(o)) using the whole-cell patch-clamp technique. Increasing the pH(o) from 7.4 to 8.0 decreased the magnitude of Cl(ir) current by shifting the open probability to more negative membrane potentials with little… (More)

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Cite this paper

@article{Arreola2002ConformationdependentRO, title={Conformation-dependent regulation of inward rectifier chloride channel gating by extracellular protons.}, author={Jorge Arreola and Ted Begenisich and James E Melvin}, journal={The Journal of physiology}, year={2002}, volume={541 Pt 1}, pages={103-12} }