Conformation as the determinant of saccharide binding in concanavalin A: Ca2+-concanavalin A complexes.

@article{Koenig1978ConformationAT,
  title={Conformation as the determinant of saccharide binding in concanavalin A: Ca2+-concanavalin A complexes.},
  author={S. Koenig and C. Brewer and R. D. Brown},
  journal={Biochemistry},
  year={1978},
  volume={17 20},
  pages={
          4251-60
        }
}
  • S. Koenig, C. Brewer, R. D. Brown
  • Published 1978
  • Chemistry, Medicine
  • Biochemistry
  • The existence of two conformational states of concanavalin A (Con A) with different metal ion binding properties has been recently demonstrated (Brown, R. D., Brewer, C. F., & Koenig, S. H. (1977) Biochemistry 16, 3883). Introduction of Mn2+ to the S1 site and Ca2+ to the S2 site of apo-Con A was shown to induce a conformational change in the protein, ascribed to a cis-trans isomerization of a peptide bond in the secondary structure, which results in extremely tight binding of the metal ions… CONTINUE READING
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