Conformation and ion-binding of oligonucleotides.

  title={Conformation and ion-binding of oligonucleotides.},
  author={A K Kontturi and Ky{\"o}sti Kontturi and Arto Urtti},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  volume={15 4},
The effective charge and the conformation of oligonucleotides may influence their pharmaceutical properties. Therefore, a method based on the convective diffusion process was used to measure both the diffusion coefficient and the effective charge number of four oligonucleotides with different chain lengths. Determinations were carried out at physiological… CONTINUE READING