Confocal microscopic localization of constitutive and heat shock-induced proteins HSP70 and HSP27 in the rat heart.

@article{Leger2000ConfocalML,
  title={Confocal microscopic localization of constitutive and heat shock-induced proteins HSP70 and HSP27 in the rat heart.},
  author={James P L Leger and Frank M. Smith and R. William Currie},
  journal={Circulation},
  year={2000},
  volume={102 14},
  pages={1703-9}
}
BACKGROUND Heat-shock treatment of rats elevates expression of heat-shock proteins, which play a role in improving the contractile recovery and reducing infarct size in hearts after ischemic injury. However, the location of these proteins in the heart is unknown. METHODS AND RESULTS Anesthetized rats were heat-shocked by elevation of body temperature to 42 degrees C to 42.5 degrees C for 15 minutes, followed by 24 hours of recovery. Control and heat-shocked hearts were extirpated and perfused… CONTINUE READING
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