Confocal endomicroscopy identifies loss of local barrier function in the duodenum of patients with Crohn's disease and ulcerative colitis.

@article{Lim2014ConfocalEI,
  title={Confocal endomicroscopy identifies loss of local barrier function in the duodenum of patients with Crohn's disease and ulcerative colitis.},
  author={Lee Guan Lim and Janina Neumann and Torsten Hansen and Martin Goetz and Arthur E. Hoffman and Markus F Neurath and Peter Robert Galle and Yiong Huak Chan and Ralf Kiesslich and A J M Watson},
  journal={Inflammatory bowel diseases},
  year={2014},
  volume={20 5},
  pages={
          892-900
        }
}
BACKGROUND Increased cell shedding with gap formation and local barrier dysfunction can be identified endomicroscopically in the terminal ileum of patients with inflammatory bowel disease. We aim to evaluate whether these changes are also present in the duodenum of patients with inflammatory bowel disease. METHODS Fifteen patients with Crohn's disease (CD), 10 patients with ulcerative colitis (UC), and 10 controls underwent fluorescein-aided confocal laser endomicroscopy (CLE). CLE was… CONTINUE READING

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