Conflicting roles for p63 in skin development and carcinogenesis.


Epidermal morphogenesis is a complex process that culminates in the formation of a barrier that protects the organism from environmental substances and dehydration. p63, a transcription factor, is essential for normal epidermal morphogenesis as demonstrated by the failure of mice lacking p63 expression to develop an epidermis. However, since two independently generated p63(-/-) mouse models displayed different phenotypes, the role of p63 in epidermal morphogenesis has remained controversial. Furthermore, the tumor susceptibility phenotypes of both p63(-/-) mouse models were strikingly different. In this review, we discuss these conflicting findings and provide evidence for various roles of p63 in the epidermis under normal and pathological conditions.


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@article{Koster2007ConflictingRF, title={Conflicting roles for p63 in skin development and carcinogenesis.}, author={Maranke I. Koster and Daisy Dai and Dennis R. Roop}, journal={Cell cycle}, year={2007}, volume={6 3}, pages={269-73} }