Conflicting levels of selection in the accumulation of mitochondrial defects in Saccharomyces cerevisiae.

@article{Taylor2002ConflictingLO,
  title={Conflicting levels of selection in the accumulation of mitochondrial defects in Saccharomyces cerevisiae.},
  author={Douglas R. Taylor and C. van Zeyl and Erin Cooke},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 6},
  pages={3690-4}
}
The somatic accumulation of defective mitochondria causes human degenerative syndromes, senescence in fungi, and male sterility in plants. These diverse phenomena may result from conflicts between natural selection at different levels of organization. Such conflicts are fundamental to the evolution of cooperating groups, from cells to populations. We present a model in which defective mitochondrial genomes accumulate because of a within-cell replication advantage when among-cell selection for… CONTINUE READING
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