Conflicting data on the prognostic significance of FLT3/TKD mutations in acute myeloid leukemia might be related to the incidence of biallelic disease.

Abstract

We read with interest the paper from Whitman and colleagues1 reporting an adverse impact on disease-free survival of FLT3 tyrosine kinase domain (FLT3/TKD) mutations in 19 of 217 patients with normal karyotype acute myeloid leukemia (AML). This contrasts with our data where the presence of FLT3/TKD mutations in 127 of 1107 nonacute promyelocytic leukemia… (More)
DOI: 10.1182/blood-2008-02-140392

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Cite this paper

@article{Mead2008ConflictingDO, title={Conflicting data on the prognostic significance of FLT3/TKD mutations in acute myeloid leukemia might be related to the incidence of biallelic disease.}, author={Adam J Mead and Rosemary E Gale and Robert K. Hills and Manu Gupta and Bryan D. Young and Alan K. Burnett and David C. Linch}, journal={Blood}, year={2008}, volume={112 2}, pages={444-5; author reply 445} }