Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice.

@article{Judge2009ConfirmingTR,
  title={Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice.},
  author={Adam D. Judge and Marjorie Robbins and Iran Tavakoli and Jasna Levi and Lina Hu and Anna Fronda and Ellen G. Ambegia and Kevin D McClintock and Ian Maclachlan},
  journal={The Journal of clinical investigation},
  year={2009},
  volume={119 3},
  pages={661-73}
}
siRNAs that specifically silence the expression of cancer-related genes offer a therapeutic approach in oncology. However, it remains critical to determine the true mechanism of their therapeutic effects. Here, we describe the preclinical development of chemically modified siRNA targeting the essential cell-cycle proteins polo-like kinase 1 (PLK1) and kinesin spindle protein (KSP) in mice. siRNA formulated in stable nucleic acid lipid particles (SNALP) displayed potent antitumor efficacy in… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 122 extracted citations

Structure-activity relationships of siRNA carriers based on sequence-defined oligo (ethane amino) amides.

Journal of controlled release : official journal of the Controlled Release Society • 2012
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-2 of 2 references

Similar Papers

Loading similar papers…