Confirmation of the HOXB13 G84E germline mutation in familial prostate cancer.

  title={Confirmation of the HOXB13 G84E germline mutation in familial prostate cancer.},
  author={Joan P. Breyer and T. Grant Avritt and Kate M. McReynolds and William D. Dupont and Jeffrey R. Smith},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={21 8},
BACKGROUND A recent study of familial and early onset prostate cancer reported a recurrent rare germline mutation of HOXB13 among men of European descent. The gene resides within the 17q21 hereditary prostate cancer linkage interval. METHODS We evaluated the G84E germline mutation (rs138213197) of HOXB13 in a case-control study of familial prostate cancer at Vanderbilt University (Nashville, TN) to independently evaluate the association of the mutation with familial prostate cancer. We… CONTINUE READING
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