Confirmation of primary active substances from high throughput screening of chemical and biological populations: a statistical approach and practical considerations.

@article{Zhang2000ConfirmationOP,
  title={Confirmation of primary active substances from high throughput screening of chemical and biological populations: a statistical approach and practical considerations.},
  author={J. H. Zhang and Thomas D Y Chung and Kevin R Oldenburg},
  journal={Journal of combinatorial chemistry},
  year={2000},
  volume={2 3},
  pages={258-65}
}
Many biologically important substances are discovered through screening of relevant chemical or biological libraries. The ability to find the active substances ("hits") from any random collection is largely determined by the quality of the assay and screening conditions. When a large population is screened for a specific characteristic, each member of that population is usually tested only once. Errors in the measurements require additional follow-up tests to confirm that each hit from the… CONTINUE READING

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