Confirmation of linkage of Duane's syndrome and refinement of the disease locus to an 8.8-cM interval on chromosome 2q31

@article{Evans2000ConfirmationOL,
  title={Confirmation of linkage of Duane's syndrome and refinement of the disease locus to an 8.8-cM interval on chromosome 2q31},
  author={Julie Claire Evans and Timothy M. Frayling and Sian Ellard and Nicholas J. Gutowski},
  journal={Human Genetics},
  year={2000},
  volume={106},
  pages={636-638}
}
Duane's syndrome is a congenital abnormality of eye movement, which may be inherited as an autosomal dominant trait but usually occurs sporadically. Genetic mapping in a Mexican family has recently identified a locus for Duane's syndrome within a 17.8-cM region of chromosome 2q31. The region was flanked by the microsatellite markers D2S2330 and D2S364. We performed linkage and haplotype analysis in a four-generation UK family with autosomal dominant transmission of Duane's syndrome. Linkage to… CONTINUE READING

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