Confirmation of gestational exposure to alprazolam by analysis of biological matrices in a newborn with neonatal sepsis

  title={Confirmation of gestational exposure to alprazolam by analysis of biological matrices in a newborn with neonatal sepsis},
  author={{\'O}. Garc{\'i}a-Algar and M. A. L{\'o}pez-Vilchez and I. Mart{\'i}n and A. Mǔr and M. Pellegrini and R. Pacifici and S. Rossi and S. Pichini},
  journal={Clinical Toxicology},
  pages={295 - 298}
  • Ó. García-Algar, M. A. López-Vilchez, +5 authors S. Pichini
  • Published 2007
  • Medicine
  • Clinical Toxicology
  • Background. Different biological matrices are suitable for drug testing in newborns presenting with an acute withdrawal syndrome. Case report. The newborn of a mother reporting alprazolam use during pregnancy presented with respiratory distress and clinical features consistent with neonatal withdrawal syndrome or neonatal sepsis of vertical transmission. Alprazolam and its main metabolite (α-hydroxyalprazolam) were detected in cord serum, neonatal urine and also in neonatal hair, meconium and… CONTINUE READING
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