Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa

@article{Happi2006ConfirmationOE,
  title={Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa},
  author={Christian Tientcha Happi and Grace Olusola Gbotosho and Onikepe Abiola Folarin and Danny Milner and Ousmane Fall Sarr and A. Sowunmi and Dennis E. Kyle and Wilbur K. Milhous and Dyann F Wirth and Ayoade M. J. Oduola},
  journal={Malaria Journal},
  year={2006},
  volume={5},
  pages={82 - 82}
}
In vitro and in vivo resistance of Plasmodium falciparum to atovaquone or atovaquone-proguanil hydrochloride combination has been associated to two point mutations in the parasite cytochrome b (cytb) gene (Tyr268Ser and Tyr268Asn). However, little is known about the prevalence of codon-268 mutations in natural populations of P. falciparum without previous exposure to the drug in Africa. The prevalence of codon-268 mutations in the cytb gene of African P. falciparum isolates from Nigeria, Malawi… CONTINUE READING

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