Configuration of necine pyrroles--toxic metabolites of pyrrolizidine alkaloids.

  title={Configuration of necine pyrroles--toxic metabolites of pyrrolizidine alkaloids.},
  author={Bartłomiej Kedzierski and Donald R. Buhler},
  journal={Toxicology letters},
  volume={25 2},
The commonly accepted belief regarding the configuration of the major pyrrole metabolite of pyrrolizidine alkaloids has been revised. This paper provides evidence that a racemic mixture of (+/-) 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine is the product of the microsomal transformation of esters of heliotridine and retronecine instead of pure(+) or (-) enantiomers, commonly referred to as dehydroheliotridine and dehydroretronecine. The toxicological significance of these results is… CONTINUE READING
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