Configuration of human dendritic cell cytoskeleton by Rho GTPases, the WAS protein, and differentiation.

  title={Configuration of human dendritic cell cytoskeleton by Rho GTPases, the WAS protein, and differentiation.},
  author={Siobhan O. Burns and Adrian J. Thrasher and Michael Patrick Blundell and Laura Machesky and Gareth E Jones},
  volume={98 4},
The cellular mechanisms that configure the cytoskeleton during migration of dendritic cells (DCs) are poorly understood. Immature DCs assemble specialized adhesion structures known as podosomes at their leading edge; these are associated with the localized recruitment of the Wiskott-Aldrich Syndrome protein (WASp) and the actin organizing actin-related protein 2/3 complex. In immature DCs lacking WASp, podosomes are absent, residual dysmorphic lamellipodia and filopodia are nonpolarized, and… CONTINUE READING

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