Confidence intervals for cost-effectiveness ratios: a comparison of four methods.

  title={Confidence intervals for cost-effectiveness ratios: a comparison of four methods.},
  author={Daniel E. Polsky and Henry A. Glick and Richard J. Willke and Kevin A. Schulman},
  journal={Health economics},
  volume={6 3},
We evaluated four methods for computing confidence intervals for cost-effectiveness ratios developed from randomized controlled trials: the box method, the Taylor series method, the nonparametric bootstrap method and the Fieller theorem method. We performed a Monte Carlo experiment to compare these methods. We investigated the relative performance of each method and assessed whether or not it was affected by differing distributions of costs (normal and log normal) and effects (10% absolute… CONTINUE READING

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