Confers Survival Advantage in pre-BI Cells Down-modulation of CD 19 , Enhances Migration to CXCL 12 , PAX 5 / TEL Acts as a Transcriptional Repressor Causing

@inproceedings{Fazio2007ConfersSA,
  title={Confers Survival Advantage in pre-BI Cells Down-modulation of CD 19 , Enhances Migration to CXCL 12 , PAX 5 / TEL Acts as a Transcriptional Repressor Causing},
  author={Grazia Fazio and Chiara Palmi and Antonius G. Rolink and Andrea Biondi and Giovanni Cazzaniga},
  year={2007}
}
PAX5 is a transcription factor essential for B-cell development. Recently, it has been found as a frequent target of aberrancies in childhood acute lymphoblastic leukemia (ALL; 30% of B cell ALL cases), showing monoallelic loss, point mutations, or chromosomal translocations. The role of these aberrancies is still poorly understood. We previously cloned the… CONTINUE READING