Cones respond to light in the absence of transducin β subunit.

  title={Cones respond to light in the absence of transducin β subunit.},
  author={Sergei S. Nikonov and Arkady L. Lyubarsky and Marie E. Fina and Elena S Nikonova and Abhishek Sengupta and Chidambaram Chinniah and X Ding and Robert G. Smith and Edward N Pugh and Noga Vardi and Anuradha Dhingra},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={33 12},
Mammalian cones respond to light by closing a cGMP-gated channel via a cascade that includes a heterotrimeric G-protein, cone transducin, comprising Gαt2, Gβ3 and Gγt2 subunits. The function of Gβγ in this cascade has not been examined. Here, we investigate the role of Gβ3 by assessing cone structure and function in Gβ3-null mouse (Gnb3(-/-)). We found that Gβ3 is required for the normal expression of its partners, because in the Gnb3(-/-) cone outer segments, the levels of Gαt2 and Gγt2 are… CONTINUE READING