Cone and plate(let) analyzer: monitoring glycoprotein IIb/IIIa antagonists and von Willebrand disease replacement therapy by testing platelet deposition under flow conditions.

@article{Varon1998ConeAP,
  title={Cone and plate(let) analyzer: monitoring glycoprotein IIb/IIIa antagonists and von Willebrand disease replacement therapy by testing platelet deposition under flow conditions.},
  author={David Varon and I Lashevski and Brigitte Brenner and Rafael Beyar and Noami Lanir and Ilia Tamarin and Naphtali Savion},
  journal={American heart journal},
  year={1998},
  volume={135 5 Pt 2 Su},
  pages={S187-93}
}
Exposure of citrated whole blood samples to polystyrene plates under flow conditions with the cone and plate(let) analyzer (CPA) results in surface immobilization of plasma von Willebrand factor (vWF) followed by platelet deposition. Staining the plates allows measurement of the percentage of surface covered (SC) by the adhered particles and their average size (AS). Both SC and AS parameters depend on platelet count and hematocrit level and reach maximal values after 2 minutes; only AS is shear… CONTINUE READING

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