Conduction velocity depression and drug-induced ventricular tachyarrhythmias. Effects of lidocaine in the intact canine heart.

@article{Anderson1990ConductionVD,
  title={Conduction velocity depression and drug-induced ventricular tachyarrhythmias. Effects of lidocaine in the intact canine heart.},
  author={Kelley P. Anderson and Robert William Walker and Robert L. Lux and Philip R. Ershler and Ronald L. Menlove and Mathew Russell Williams and Rebecca McNall Krall and Dave S. Moddrelle},
  journal={Circulation},
  year={1990},
  volume={81 3},
  pages={
          1024-38
        }
}
Depression of myocardial conduction velocity can be an important mechanism of action of antiarrhythmic drugs but it can also facilitate arrhythmogenesis. We used lidocaine in an anesthetized canine preparation to address the hypothesis that drug-induced rate-dependent conduction velocity depression causes ventricular tachyarrhythmias. A closely spaced square array of 64 electrodes was used to determine conduction velocity longitudinal and transverse to epicardial ventricular fiber direction… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 75 REFERENCES

Comparison of estimates of activation and recovery times from bipolar and unipolar electrograms to in vivo transmembrane action potential durations

RF Wyatt
  • IEEE 1980 Frontiers Eng Health Care
  • 1990

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