Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43.

@article{Gutstein2001ConductionSA,
  title={Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43.},
  author={David E. Gutstein and Gregory E. Morley and Houman Tamaddon and Dhananjay Vaidya and Michael H. Schneider and Junjie Chen and Kenneth R. Chien and Heidi Stuhlmann and Glenn I. Fishman},
  journal={Circulation research},
  year={2001},
  volume={88 3},
  pages={333-9}
}
Cardiac arrhythmia is a common and often lethal manifestation of many forms of heart disease. Gap junction remodeling has been postulated to contribute to the increased propensity for arrhythmogenesis in diseased myocardium, although a causative role in vivo remains speculative. By generating mice with cardiac-restricted knockout of connexin43 (Cx43), we have circumvented the perinatal lethal developmental defect associated with germline inactivation of this gap junction channel gene and… CONTINUE READING
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