Conduction mechanisms of chloride ions in ClC-type channels.

  title={Conduction mechanisms of chloride ions in ClC-type channels.},
  author={Ben Corry and Megan L. O'Mara and Shin-Ho Chung},
  journal={Biophysical journal},
  volume={86 2},
The conduction properties of ClC-0 and ClC-1 chloride channels are examined using electrostatic calculations and three-dimensional Brownian dynamics simulations. We create an open-state configuration of the prokaryotic ClC Cl(-) channel using its known crystallographic structure as a basis. Two residues that are occluding the channel are slowly pushed outward with molecular dynamics to create a continuous ion-conducting path with the minimum radius of 2.5 A. Then, retaining the same pore shape… CONTINUE READING
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