Conditions that affect sleep alter the expression of molecules associated with synaptic plasticity.

  title={Conditions that affect sleep alter the expression of molecules associated with synaptic plasticity.},
  author={Ping Taishi and Cristina De Ram{\'o}n S{\'a}nchez and Yuliang Wang and Jidong Fang and Joseph W. Harding and James M. Krueger},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={281 3},
Many theories propose that sleep serves a purpose in synaptic plasticity. We tested the hypothesis, therefore, that manipulation of sleep would affect the expression of molecules known to be involved in synaptic plasticity. mRNA expression of four molecules [brain-derived neurotrophic factor (BDNF), activity-regulated cytoskeleton-associated protein (Arc), matrix metalloproteinase-9 (MMP-9), and tissue plasminogen activator (tPA)] was determined after 8 h of sleep deprivation and after 6 h of a… CONTINUE READING


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