Conditions of retinal glial and inflammatory cell activation after irradiation in a GFP-chimeric mouse model.

@article{Muether2010ConditionsOR,
  title={Conditions of retinal glial and inflammatory cell activation after irradiation in a GFP-chimeric mouse model.},
  author={Philipp Sebastian Muether and Irina Semkova and Kristina Runge Schmidt and Elizabeth Abari and Marc Kuebbeler and Marc Beyer and Hinrich Abken and Klaus L. Meyer and Norbert Kociok and Antonia Maria Joussen},
  journal={Investigative ophthalmology & visual science},
  year={2010},
  volume={51 9},
  pages={4831-9}
}
PURPOSE Microglia cells have been associated with immunologic defense and repair. The course of retinal disease after lethal irradiation for bone marrow depletion and substitution was evaluated with respect to macrophage and microglial involvement. METHODS Lethal irradiation in C57BL/6 mice was conducted with a low-voltage radiation unit. The animals were randomized to shielded or unshielded radiation and subsequently received transplants of GFP+ bone marrow cells (beta-actin promoter). The… CONTINUE READING

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