Conditions for extreme sensitivity of protein diffusion in membranes to cell environments.

Abstract

We study protein diffusion in multicomponent lipid membranes close to a rigid substrate separated by a layer of viscous fluid. The large-distance, long-time asymptotics for Brownian motion are calculated by using a nonlinear stochastic Navier-Stokes equation including the effect of friction with the substrate. The advective nonlinearity, neglected in previous treatments, gives only a small correction to the renormalized viscosity and diffusion coefficient at room temperature. We find, however, that in realistic multicomponent lipid mixtures, close to a critical point for phase separation, protein diffusion acquires a strong power-law dependence on temperature and the distance to the substrate H, making it much more sensitive to cell environment, unlike the logarithmic dependence on H and very small thermal correction away from the critical point.

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@article{Tserkovnyak2006ConditionsFE, title={Conditions for extreme sensitivity of protein diffusion in membranes to cell environments.}, author={Y. Tserkovnyak and David R. Nelson}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2006}, volume={103 41}, pages={15002-7} }