Conditions for Purine Synthesis: Did Prebiotic Synthesis Occur at Low Temperatures?

@article{Sanchez1966ConditionsFP,
  title={Conditions for Purine Synthesis: Did Prebiotic Synthesis Occur at Low Temperatures?},
  author={Robert A. Sanchez and James P. Ferris and Leslie E. Orgel},
  journal={Science},
  year={1966},
  volume={153},
  pages={72 - 73}
}
The rate of polymerization of hydrogen cyanide to aminomalononitrile and the tetramer, diaminomalonodinitrile, is quadratic in the total cyanide concentration. Since the reactions form part of a plausible prebiotic purine synthesis and since they compete with hydrolysis, concentration of cyanide may have been important. This may be achieved usefully by cooling to separate out ice. 
Prebiotic adenine synthesis via HCN oligomerization in ice.
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The results confirm and extend an earlier suggestion that purine synthesis on the prebiotic Earth might have occurred in frozen, dilute solutions of HCN. Expand
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A number of potentially prebiotic processes to produce condensed phosphates from orthophosphate and cyclic trimetaphosphate from tripolyphosphate are investigated, finding them not sufficiently robust to have been of importance in the prebiotics open ocean. Expand
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It is shown here that dilute solutions of simple prebiotic molecules produce the biological pyrimidines cytosine and uracil upon freezing upon freezing. Expand
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It is suggested that eutectic freezing is the most plausible demonstrated mechanism by which HCN polymerizations could have produced biologically important prebiotic compounds. Expand
A possible prebiotic synthesis of purine, adenine, cytosine, and 4(3H)-pyrimidinone from formamide: implications for the origin of life.
TLDR
A plausible new prebiotic synthesis of naturally occurring purine and pyrimidine derivatives from formamide under catalytic conditions is reported here and the role of catalysts showed to be not only relevant in providing a high selectivity in the products distribution. Expand
Chemical evolution XXIX. Pyrimidines from hydrogen cyanide.
TLDR
The observation of the formation of orotic acid and 4-aminoimidazole-5-carboxamide by the hydrolysis of the HCN oligomers suggests that once the initially formed pyrimidines and purines were consumed, those life forms persisted which evolved enzymes for conversion of these intermediates to the pyrimidine and purine present in contemporary RNA. Expand
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