Conditions That Induce Tolerance in Mature CD 4 1 T Cells


Establishment of antigen-specific tolerance among mature T cells has been a long debated, yet poorly understood issue. In this study we have used transgenic mice bearing a class II–restricted TCR specific for the hemmagglutinin of the influenza virus in order to test the behavior of CD4 1 T cells upon exposure to antigen in different forms and doses. We first studied the fate of T cells expressing the transgenic TCR (6.5) in double transgenic mice where HA was expressed as a self antigen by hemapoietic cells. In these mice, we found some mature T cells in periphery that had escaped thymic deletion and that showed signs of activation but which were anergic. Mature CD4 1 6.5 1 cells that were transferred into antigen-containing recipients went through an initial phase of expansion after which most cells were deleted and those remaining became unresponsive, as previously described for CD8 1 cells. Inducing tolerance in CD4 1 6.5 1

8 Figures and Tables


Citations per Year

578 Citations

Semantic Scholar estimates that this publication has 578 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@inproceedings{Lanoue1997ConditionsTI, title={Conditions That Induce Tolerance in Mature CD 4 1 T Cells}, author={Astrid Lanoue and Constantin A. Bona and Harald von Boehmer and Adelaida Sarukh{\'a}n}, year={1997} }