Conditioning regimens for allotransplants for diffuse large B-cell lymphoma: myeloablative or reduced intensity?

@article{Bacher2012ConditioningRF,
  title={Conditioning regimens for allotransplants for diffuse large B-cell lymphoma: myeloablative or reduced intensity?},
  author={Ulrike Bacher and Evgeny Klyuchnikov and Jennifer G Le-Rademacher and Jeanette Carreras and Philippe F Armand and Michael R. Bishop and Christopher N. Bredeson and Mitchell S Cairo and Timothy S. Fenske and Cesar Freytes and Robert Peter Gale and John O Gibson and Luis M. Isola and David James Inwards and Ginna G. Laport and Hillard M Lazarus and Richard T Maziarz and Peter H. Wiernik and Harry C. Schouten and Shimon Slavin and Sonali M Smith and Julie Marie Vose and Edmund K Waller and Parameswaran N. Hari},
  journal={Blood},
  year={2012},
  volume={120 20},
  pages={4256-62}
}
The best conditioning regimen before allogeneic transplantation for high-risk diffuse large B-cell lymphoma (DLBCL) remains to be clarified. We analyzed data from 396 recipients of allotransplants for DLBCL receiving myeloablative (MAC; n = 165), reduced intensity (RIC; n = 143), or nonmyeloablative conditioning (NMAC; n = 88) regimens. Acute and chronic GVHD rates were similar across the groups. Five-year nonrelapse mortality (NRM) was higher in MAC than RIC and NMAC (56% vs 47% vs 36%; P… CONTINUE READING
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