Corpus ID: 3142977

Conditioning of Nude bone marrow increases in vitro migration to thymus supernatant.

@article{Hall1992ConditioningON,
  title={Conditioning of Nude bone marrow increases in vitro migration to thymus supernatant.},
  author={Andrew J Hall and Jack L. Haar and Kevin R. McCormick and H. Massey and Ronald K. Elswick},
  journal={Thymus},
  year={1992},
  volume={20 4},
  pages={
          227-38
        }
}
  • Andrew J Hall, Jack L. Haar, +2 authors Ronald K. Elswick
  • Published in Thymus 1992
  • Biology, Medicine
  • The thymus must be continuously seeded by cells termed prothymocytes in order to maintain normal T-cell development (Scollay et al. 1986). Using parabiotic studies, the source of prothymocytes appears to be either from the fetal liver or the adult bone marrow (Roderwald et al. 1992). The ability of the body to distinguish self from non-self and mount a functionally mature immune response is dependent upon the intrathymic education of these cells. Therefore, it is apparent that successful… CONTINUE READING

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